SCISSOR N3 – PION

Scissor N3 is an in vitro model simulating subcutaneous injection of biopharmaceuticals for rank ordering formulations and excipient screening during formulation development.

• Understand in vitro how a drug behaves after subcutaneous injection and the impact this has on drug release with our Scissor N3.
• Possible precipitation events can be monitored and correlated to lymphatic and systemic release dynamics quantified in the system.
• Reduce the reliance on inaccurate animal models and select formulation candidates with confidence based on bio-relevant information gained earlier in the development process, saving in both cost and time.
• Scissor allows users to screen excipients and compare different formulations to identify the best candidates for further development.
• The Scissor N3 mimics the stresses a biopharmaceutical experiences when transitioning from formulation conditions to a subcutaneous environment.
• Compatible with an optional fraction collector.

Coupled with the Rainbow R6 in-situ fiber optic UV-vis spectrometer, lymphatic and systemic release data can be measured in-situ giving real-time results and enriching the data collection process.

Sample aliquots can also be collected with an additional external fraction collector to allow for offline analysis with any preferred analytical method facilitating more in-depth research.